Lester R. Drewes, PhD
Professor, Medical School, Duluth Campus
Professor, Medical School, Duluth Campus
Adjunct Professor, Department of Pharmacy Practice and Pharmaceutical Sciences
Adjunct and Graduate Faculty Member, College of Pharmacy - Duluth
Director, Steering Committee, Brain Barriers Research Center, College of Pharmacy
Assistant to the Deans, Ph.D. Graduate Programs Duluth, College of Pharmacy - Duluth
Associate Director of Graduate Studies, Biochemistry, Molecular Biology, and Biophysics
Postdoctoral Fellow, University of Wisconsin, Madison, 1970-1973
PhD, University of Minnesota, 1970
BS, Capital University, Columbus OH Chemistry, 1965
Assistant Scientist, University of Wisconsin, Madison, Physiology and Neurosurgery, 1973-1976
Awards & Recognition
University of Minnesota External Sources
University of Minnesota
See full list of publications at: PubMed
Smith, J.P., Uhernik, A.L., Li, L., Liu, Z., and Drewes, L.R. (2012). Regulation of Mct1 by cAMP-dependent internationalization in rat brain endothelial cells. Brain Res 1480:1-11.
Drewes, L.R. (2012). Making connexons in the neurovascular unit. J Cereb Blood Flow Metab 32(8): 1455-6.
Neuwelt, E., Bauer, B., Fahlke, C., Fricker, G., Iadecola, C., Janigro, D., Leybaert, L., Molnar, Z., O'Donnell, M. E., Povlishock, J. T., Saunders, N. R., Sharp, F., Stanimirovic, D., Watts, R. J., and L.R. Drewes (2011) Engaging Neuroscience to Advance Brain Barriers Translational Research, Nature Reviews Neuroscience13:169-184
Klein, A.H., Wendroth, S., Drewes, L.R. and M.T. Andrews (2010) Hibernation strategies to improve recovery from hemorrhagic shock in rats. Shock, 34:565-572.
Andrews, M.T., Russeth, K.P., Drewes, L.R., and P.-G. Henry (2009) Adaptive mechanisms regulate preferred utilization of ketones in the heart and brain of a hibernating mammal. Am J Physiol Regul Integr Comp Physiol. 296:R383-93
Neuwelt, E., Abbott, N.J., Abrey, L., Banks, W.A., Blakley, B., Davis, T. Engelhardt, B., Grammas, P., Nedergaard, M., Nutt, J., Pardridge, W. Rosenberg, G.A., Smith, Q., and L.R. Drewes (2008) Strategies for Advancing Brain-Barriers Translational Research. Lancet Neurology 7:84-96
Henry, P.-G., Russeth, K.P., Tkac, I., Drewes, L.R., Andrews, M.T., and R. Gruetter (2007) Brain energy metabolism and neurotransmission at near-freezing temperatures: an in vivo 1H MRS study of a hibernating mammal. J. Neurochem. 101:1505-1515.
Westholm, D.E., Stenehjem, D.D., Rumbley, J.N., Drewes, L.R., and G.W. Anderson (2007) Organic anion transporting polypeptide 1c1 thyroxine transport is competitively inhibited by the fenamate class of nonsteroidal anti-inflammatory drugs. Endocrinology. 150:1025-32
Smith, J.P., and Drewes, L.R. (2006) Modulation of monocarboxylic acid transporter-1 kinetic function by the cAMP signaling pathway in rat brain endothelial cells. J. Biol. Chem. 281:2053-2060.
Enerson, B.E. and Drewes, L.R. (2006) The rat blood-brain barrier transcriptome. J. Cereb. Blood Flow Metab. 26:959-973.
Doolittle, N.D., Abrey, L.E., Bleyer, W.A., Brem, S., Davis, T.P., Dore-Duffy, P., Drewes, L.R., Hall, W.A., Hoffman, J.M., Korfel, A., Martuza, R., Muldoon, L.L., Peereboom, D., Peterson, D.R., Rabkin, S.D., Smith, Q., Stevens, G.H.J., and Neuwelt, E.A. (2005) New Frontiers in Translational Research in Neuro-oncology and the Blood-Brain Barrier: Report of the Tenth Annual Blood-Brain Barrier Disruption Consortium Meeting. Clin. Cancer Res. 11:421-428.
Enerson, B.E., and Drewes, L.R. (2003) Molecular features, regulation and function of monocarboxylate transporters: Implications for drug delivery. J. Pharm. Sci. 92:1531-1544.
Régina, A., Morchoisne, S., Borson, N.D., McCall, A.L., Drewes, L.R., and Roux, F. (2001) Factors released by glucose-derived astrocytes enhance glucose transporter expression and activity in rat brain endothelial cells. Biochim. Biophys. Acta. 1540:233-242.
Drewes, L.R., and Betz, A.L. (eds.) (1993) Frontiers in Cerebral Vascular Biology: Transport and Its Regulation, Plenum Press, New York.
Chapters in Books, Editorials, & Reports
Matson, C. and Drewes, L.R. (2003) “Detection of Endothelial Proteins by Western Blotting in Methods in Molecular Biology.” Volume X, in The Blood Brain Barrier: Biology and Research Protocols (S. Nag, ed.), p. 479-487.
Anderson, R., Drewes, L., Ntambi, J., Rapoport, S., Hibbeln, J., Yavin, E., Horrocks, L., Moore, S., Salem, N., Preuss, M., Spector, A., Lagarde, M., Kim, H.Y., and Horrobin, D. (2001) Brain uptake and utilization of fatty acids: Applications to peroxisomal biogenesis disorders (An International Workshop) - Roundtable discussion of Session 3: "The regulation and functions of DHA in neurons and neuronal membranes."J. Mol. Neurosci.16(2-3):279-84. (Editorial)
Drewes, L.R., Gerhart, D.Z., Leino, R.L., and Enerson, B.E. (2001) Expression and Modulation of Blood-brain Monocarboxylate Transporters, in The Blood-brain Barrier (D. Koliber, ed.) Kluwer, Amsterdam. p. 9-17.
University of Minnesota Medical School Duluth/UMD
Medical School Courses
- 23 Principles in Basic Medical Science Nervous System
- Problem-Based Learning (Facilitator)
- Cell and Molecular Biology (member of team faculty)
- Neurosciences/Nervous System (member of team faculty)
- Gastrointestinal Hepatobiliary System
- Medical Biochemistry Biochemistry of Specialized Tissues Acid-Base Balance (at University of Wisconsin Medical School)
Graduate/Medical School Courses
- Neuroscience (Neurobiochemistry)
- Integrated BioSciences
- Biochemistry Biochemistry Laboratory
- Biochemistry Research
- Advanced Biochemistry
- Advanced Biochemical Techniques
- Cell and Molecular Biology Toxicology (member of faculty team)
- Clinical Science (Fluids, Electrolytes, and Acid-Base Balance)
- Neurosciences (Guest Lecturer, University of Miami, School of Medicine)
- Survey of Biochemistry Undergraduate Research in Chemistry (Biochemistry)
Mentoring & Advising
- Graduate Students
- Postdoctoral Associates
PROFESSIONAL SERVICE AND PUBLIC OUTREACH
- Editor-in-Chief, Fluids and Barriers in the CNS 2013-present
- Honorary Editor, Fluids and Barriers in the CNS 2011-2013
- Member, Editorial Review Board of the Journal of Cerebral Blood Flow and Metabolism, 1989-1996, 2002-present
- Member, Editorial Review Board of the Journal of Neurochemistry 1993-1998
- Member, Editorial Review Board of the Journal of Biological Chemistry 2002-2009