Jean F. Regal, PhD
Professor, Pharmacology, Department of Biomedical Sciences
Professor, Pharmacology, Department of Biomedical Sciences
PhD, Pharmacology, University of Minnesota, 1977
The overall goals of my research program involve understanding basic immune mechanisms of cardiopulmonary disease. I have a long-standing interest in the complement system as a mediator of adverse events in disease states such as anaphylaxis, asthma and most currently pregnancy-induced hypertension. These interests have also involved defining mechanisms of pulmonary immunotoxicity of small molecule workplace allergens such as trimellitic anhydride. My research approach involves experimentation at the molecular, biochemical and physiological levels using animal models of disease. Current research projects include:
Preeclampsia and related hypertensive disorders of pregnancy affect ~10% of all pregnancies in the United States, significantly impacting the health of both mother and child. The initiating event of preeclampsia involves impaired blood flow to the placenta and the end result for the mother is high blood pressure and protein in the urine, along with growth restriction in the fetus. During pregnancy, the immune system including the plasma complement system, is tightly regulated to allow fetal survival. In women with preeclampsia the complement system is excessively activated, and our long term goal is to determine the therapeutic utility of manipulating the complement system to prevent preeclampsia or minimize consequences for the mother and child. We hypothesized that complement system activation and white blood cell recruitment lead to hypertension in the mother and growth restriction in the fetus. Thus we are manipulating the complement system and white blood cell function in a model of placental ischemia induced high blood pressure to determine the critical mechanisms responsible for the adverse events.
Research Funding Grants
My lab is currently funded through the National Heart Lung and Blood Institute of NIH.
See also: PubMed
Selected Reviews and Book Chapters
Regal, J.F. Allergic asthma and rhinitis: Toxicological considerations. In General and Applied Toxicology, 3rd ed. Ed. B. Ballantyne, T. Marrs, T. Syversen. John Wiley and Sons, Ltd, UK. In Press
Regal, J.F. and Selgrade MJ: Hypersensitivity Reactions in the Respiratory Tract. In Immune System Toxicology, Vol 5, Comprehensive Toxicology. 2nd ed. Ed. I.G. Sipes, C.A. McQueen, A.J. Gandolfi. Elsevier Science. ISBN: 978-0-08-046884-6.
Regal, J.F., Greene, A.L., and Regal, R.R.: Mechanisms of Occupational Asthma: Not all Allergens are Equal.Environmental Health and Preventive Medicine 12:161-167, 2007.
Regal, J.F.: Complement. pp. 153-158. In Encyclopedic Reference of Immunotoxicology. Ed. H-W Vohr. Springer-Verlag, Germany, 2005.
Regal, J. F. : Complement and Allergy. pp. 147-150. In Encyclopedic Reference of Immunotoxicology. Ed. H-W Vohr. Springer-Verlag, Germany, 2005.
Regal, J.F. Immunologic Effector Mechanisms in Animal Models of Occupational Asthma. J. Immunotoxicology 1:25-38, 2004.
Regal, J.F. Murine Asthma Models. Current Protocols in Toxicology. 18.3.1-18.3.21, 2004.
Regal, J.F.: Committee member and Co-author of Gulf War and Health, Volume 1: Depleted Uranium, Sarin, Pyridostigmine Bromide, and Vaccines. Institute of Medicine, National Academy Press, Washington D.C. 2000.
Roggen, E.L., Aufderheide, M., Cetin, Y., Dearman, R.J., Gibbs, S., Hermanns, I., Kimber, I., Regal, J.F., Rovida, C., Warheit, D.B., Uhlig, S., Casati, S. Progress in the Development of Novel Approaches to the Identification of Chemical and Protein Respiratory Allergens. Alternatives to Testing in Laboratory Animals36:5, 591-8.
Regal, J.F., Greene, A.L., Rutherford, M.S., Regal, R.R., Duan, M., Haynes, V., Mohrman, M.: Effectiveness of primary prevention of asthma varies with age and sex in a mouse model. Submitted to Clinical Experimental Allergy.
Regal, J.F., Regal, R.R., Meehan, J.L., Duan, M., Mohrman, M.E.: Contributions of Age and Sex to Heterogeneity of Symptoms and Effectiveness of Secondary Prevention Strategies in Asthma as Modeled in the Guinea Pig. J Immunotox 4, 1-13, 2007.
Teske, S., Bohn, A.A., Regal, J.F., Neumiller, and Lawrence, B.P.: Activation of the aryl hydrocarbon receptor increases pulmonary neutrophilia and diminishes host resistance to influenza A virus. Am J Physiol, Lung Cell Mol Physiol 289: L111-24, 2005.
Greene , A.L., Rutherford, M.S., Regal, R.R., Flickinger, G.H., Hendrickson, J.A., Giulivi, C., Mohrman, M.E., Fraser, D.G., Regal, J.F.: Arginase activity differs with allergen in the effector phase of ovalbumin- vs trimellitic anhydride-induced asthma. Toxicological Sciences 88: 420-433, 2005.
Larsen, C.P. and Regal, J.F.: Trimellitic anhydride (TMA) dust induces airway obstruction and eosinophilia in non-sensitized guinea pigs. Toxicology 178: 89-99, 2002.
Regal, J.F., Mohrman, M.E. and Sailstad, D.M.: Trimellitic anhydride-induced eosinophilia in a mouse model of occupational asthma. Toxicology and Applied Pharmacology 175:234-242, 2001.
Larsen, C.P., Regal, R.R. and Regal, J.F.: Trimellitic anhydride-induced allergic response in the guinea pig lung involves antibody-dependent and -independent complement system activation. J. Pharmacol. Exp Ther296:284-292, 2001.
Regal, J.F. and A. Klos: Minor role of the C3a receptor in systemic anaphylaxis in the guinea pig.Immunopharmacol. 46: 15-28, 2000.
Lillegard KE, Johnson AC, Lojovich SJ, Bauer AJ, Marsh H, Gilbert JS, Regal JF. Inhibitor of complement activation attenuates placental ischemia-induced hypertension in rat. The FASEB J 2012.
Johnson AC, Eskuri RS, Gilbert JS, Regal JF. Pulmonary inflammation and airway hyperresponsiveness associated with placental ischemia induced hypertension in rat dams and offspring. The FASEB J 2012.
Bauer AJ, Banek CT, Lillegard KE, Regal JF, Gilbert JS. Pravastatin attenuates hypertension and angiogenic imbalance in placental ischemia induced hypertension in the rat. The FASEB J, 2012.
Regal JF, Lawrence BP, Johnson AC, Lojovich SJ, O’Reilly MA. Neonatal Oxygen Exposure Alters Airway Hyperresponsiveness In Adult Mice But Does Not Exacerbate Allergen-Induced Inflammation. Am J Resp Crit Care Med, 2012.
Regal JF, Regal RR, Mohrman ME: Age and Sex influence primary and secondary prevention strategies for controlling asthma as modeled in the mouse. The Toxicologist CD - An official Journal of the Society of Toxicology 93, number S-1, 2010.