Kendall B. Wallace, PhD

Kendall B. Wallace
Contact info

Email
kwallace@d.umn.edu

Office Phone
218-726-8899

Fax
218-726-8014

Office Address
255 Medical School Duluth
1035 University Drive
Duluth, MN 55812

Academic Title(s)

Professor

Organizations

Biomedical Sciences, Department of

Office of Faculty Affairs

Education

Doctoral Degree
PhD, Michigan State University, 1979

Additional Education
Post Doctorate, University of Iowa

Research

Research Summary/Interests

Dr. Wallace conducts research focused primarily on the mechanisms by which foreign chemicals, including drugs and industrial and environmental pollutants, interfere with mitochondrial metabolism and genetics to bring about various metabolic diseases. His primary interest is the molecular mechanisms of pathogenesis. Agents that are being investigated include anticancer and anti-AIDS drugs, and perfluorinated chemicals to name a few. In collaboration with clinical oncologists and endocrinologists, some of this basic knowledge of the molecular regulation of mitochondrial biogenesis is being translated into developing novel strategies to enhance cancer chemotherapeutics and in the design of more effective antidiabetogenic treatment regimens.

Dr. Wallace is Past President of the Society of Toxicology, the American Board of Toxicology, and the Mitochondrial Research Society and Editor-in-Chief of the journal Toxicology. He is also the founding Director of the University-wide Ph.D. graduate program in Toxicology. Dr. Wallace serves on various scientific advisory panels for the U.S. Environmental Protection Agency, Food and Drug Administration and the U.S. Department of Health and Human Services.

Patents:
Cyclodextrin Compositions and Methods of Treating Viral Infections. March 21, 2002
SLWK Dkt No. 600.538PRV; UoM File No. Z0166
KB Wallace, MA Khan, RW Carlson, SA Rice, and MK Froberg.

Editorships:
Editor: Toxicology

Publications

See also: PubMed

Books:

Molecular Biology of the Toxic Response (eds., A. Puga and K.B. Wallace) Taylor & Francis (1998)

Free Radical Toxicology: Target Organ Toxicology Series (ed., K.B. Wallace), Taylor & Francis (1997)

Book Chapters:
Starkov, A. and Wallace, K.B. (in press). “Yin and Yang of Mitochondrial ROS Generation” In: Oxidative Stess, Disease and Cancer (ed., K. Singh).

Wallace, K.B. “Doxorubicin-induced Mitochondrial Cardiomyopathy.” In: Mitochondria in Pathogenesis (eds., J.J. Lemasters and A.-L. Nieminen). Chapter 25, pp467-488. Kluwer Academic/Plenum Publishers, New York. (2001).

Wallace, K.B. "Free Radical-Mediated Chemical Cardiomyopathies." (Chapter 11) In: Free Radical Toxicology: The Target Organ Toxicology Series (ed., K.B. Wallace). Taylor and Francis (1997).