George J. Trachte, PhD

George J. Trachte
Contact info

Email
gtracht1@d.umn.edu

Office Phone
218-726-8975

Fax
218-726-7906

Office Address
Biomed Sci Medical School Duluth
308 SMed
1035 University Dr
Duluth, MN 55812

Mailing Address
DMED Biomedical Sciences
336 SMed
D957A
1035 University Dr
Duluth, MN 55812

Titles & Organizations

Professor, Department of Biomedical Sciences

Organizational Title(s)

Course Director for Respiratory Medicine

Education

Doctoral Degree
PhD, Thomas Jefferson University (Physiology), 1979

Bachelor's Degree
BS, Pennsylvania State University (Biology), 1975

Research

Research Summary/Interests

Natriuretic peptides and their influences on the nervous system with emphasis on interactions with the sympathetic nervous system and hearing.

Publications

See also: PubMed

Trachte, G.J., and A.M. Lefer. Influence of dopamine on liver dynamics in hemorrhagic shock. Circ. Shock4:305-317, 1977.

Trachte, G.J., and A.M. Lefer. Salutary effects of dexamethasone in hemorrhagic shock. Arch. Internat. Pharmacodyn. Therap. 232:309-320, 1978.

Trachte, G.J., and A.M. Lefer. Beneficial action of a new angiotensin converting enzyme inhibitor (SQ 14,225) in hemorrhagic shock in cats. Circ. Res. 43:577-582, 1978.

Trachte, G.J. and A.M. Lefer. Effect of angiotensin II receptor blockade by (Sar1, Ala8) angiotensin II (saralasin) in hemorrhagic shock. Amer. J. Physiol. 236:H280-H285, 1979.

Lefer, A.M., G.J. Trachte, J.B. Smith, W.E. Barnette, and K.C. Nicalaou. Circulatory and platelet actions of 6,9-thio-prostacyclin (PGI2-S) in the cat. Life Sci. 25:259-264, 1979.

Trachte, G.J., and A.M. Lefer. Mechanism of the protective action of the converting enzyme inhibitor (SQ 14,225) in hemorrhagic shock. Proc. Soc. Exp. Biol. Med. 162:54-57, 1979.

Trachte, G.J. and A.M. Lefer. Inotropic and vasoactive effects of the naturally occurring angiotensins in isolated cat cardiac muscle and coronary arteries. Res. Comm. Chem. Pathol. Pharmacol. 25:419-427, 1979.

Trachte, G.J., A.M. Lefer, D. Aharony, and J.B. Smith. Potent constriction of cat coronary arteries by hydroperoxides of arachidonic acid and its blockade by anti-inflammatory agents. Prostaglandins 19:909-914, 1979.

Trachte, G.J. and A.M. Lefer. Prostaglandin-mediated vasoconstriction in isolated cat arteries. Blood Vessels17:196-201, 1980.

Feinberg, G., G.J. Trachte, M. Curtis, and A.M. Lefer. Dietary modification of the vascular effect of prostacyclin in hypertensive rats. Prostaglandins and Med. 5:235-242, 1980.

Trachte, G.J. and A.M. Lefer. Shock potentiating actions of angiotensin II infusion in cats. Circ. Shock 7:343-351, 1980.

Trachte, G.J., J.A. Ackerly and M.J. Peach. Inotropic cardiac and vascular actions of (Ala7) angiotensin analogs. J. Cardiovascular Pharmacol. 3:138-146, 1981.

Trachte, G.J. and M.J. Peach. A potent nonequilibrium angiotensin II antagonist induces only competitive inhibition of angiotensin III responses. J. Cardiovasc. Pharmacol. 5:1025-1033, 1983.

Baker, K.M., C.P. Campanile, G.J. Trachte and M.J. Peach. Identification and characterization of the rabbit angiotensin II myocardial receptor. Circ. Res. 54:286-295, 1984.

Trachte, G.J., E.J. Sybertz, M. Michener, S. Bruce Binder and M.J. Peach. angiotensin III induced modulation of neurogenic responses in the rabbit vas deferens and portal vein. Naunyn Schmiedebergs Arch. Pharmacol.326:327-333, 1984.

Trachte, G.J. and M.J. Peach. Temperature effects on octa- and hepta-peptide angiotensins. Proc. Soc. Exp. Biol. Med. 177:47-54, 1984.

Trachte, G.J. The influence of prostaglandins on neurotransmission in the rabbit isolated vas deferens.Prostaglandins 29:47-60, 1985.

Trachte, G.J. Prostacyclin mediates arachidonic acid-induced relaxation of rabbit isolated mesenteric arteries.J. Cardiovasc. Pharmacol. 8:758-764, 1986.

Trachte, G.J. A thromboxane agonist (U46619) potentiates norepinephrine efflux from adrenergic nerves. J. Pharmacol. and Exp. Ther. 237:473-477, 1986.

Saye, J., S.B. Binder, G.J. Trachte and M.J. Peach. Angiotensin peptides and PGE2 synthesis: modulation of neurogenic responses in the rabbit vas deferens. Endocrinology 119:1895-1903, 1986.

Trachte, G.J., E. Stein, and M.J. Peach. Alpha adrenergic receptors mediate angiotensin-induced prostaglandin production in the rabbit isolated vas deferens. J. Pharmacol. and Exp. Ther. 240:433-440, 1987.

Trachte, G.J. Adrenergic receptors mediating force and prostaglandin production in the rabbit vas deferens.Prostaglandins 33:25-35, 1987.

Trachte, G.J. Angiotensin effects on vas deferens adrenergic and purinergic neurotransmission. Eur. J. Pharmacol. 146:261-269, 1988.

Trachte, G.J., P.J. Hook, J.R. Kemp, E.P. Acosta, and R.J. Ziegler. Thromboxane synthesis and actions in isolated adrenergic nerve (PC12) cells. J. Pharmacol. Exp. Ther. 247:43-46, 1988.

Trachte, G.J. Adrenergic nerves mediate angiotensin-induced prostaglandin release in the rabbit vas deferens.J. Pharmacol. Exp. Ther. 246:211-217, 1988.

Drewett, J.G., G.R. Marchand, R.J. Ziegler and G.J. Trachte. Atrial natriuretic factor inhibits norepinephrine release from an adrenergic clonal cell line (PC12). Eur. J. Pharmacol. 150:175-179, 1988.

Trachte, G.J. Prostaglandins do not mediate the inhibitory effects of angiotensins II and III on autonomic neurotransmission in the rabbit vas deferens. Prostaglandins 36:215-228, 1988.

Trachte, G.J. and E. Stein. Platelet-generated thromboxane A2 enhances norepinephrine release from adrenergic nerves. J. Pharmacol. Exp. Ther. 247:1139-1145, 1988.

Trachte, G.J., S.B. Binder and M.J. Peach. Indirect evidence for separate vesicular neuronal origins of norepinephrine and ATP in the rabbit vas deferens. Eur. J. Pharmacol. 164:425-433, 1989.

Drewett, J.G., G.J. Trachte and G.R. Marchand. Atrial natriuretic factor inhibits adrenergic and purinergic neurotransmission in the rabbit isolated vas deferens. J. Pharmacol. Exp. Ther. 248:135-142, 1989.

Drewett, J.G., G.R. Marchand and G.J. Trachte. Atrial natriuretic factor inhibits adrenergic neurotransmission in rabbit isolated portal veins. American Society of Hypertension Symposium Series, Vol. 3, Advances in Atrial Peptide Research, p. 342-351, 1989.

Trachte, G.J. and E. A. Stein. Thromboxane receptor agonists enhance adrenergic neurotransmission in rabbit isolated mesenteric arteries. J. Pharmacol. Exp. Ther. 249:216-220, 1989.

Drewett, J.G., R.J. Ziegler, G.R. Marchand and G.J. Trachte. Cyclic guanosine 3',5' monophosphate mediates the inhibitory effect of atrial natriuretic factor in adrenergic, neuronal pheochromocytoma cells. J. Pharmacol. Exp. Ther. 250:428-432, 1989.

Heller, L.J., G.J. Trachte and J.F. Regal. Role of adenosine in hypoxic alterations of anaphylaxis of isolated guinea pig hearts. Amer. J. Physiol. 257:H1378-1388, 1989.

Stein, E. and G.J. Trachte. Thromboxane mimetics enhance adrenergic neurotransmission in the rabbit isolated portal vein. J. Cardiovasc. Pharmacol. 14:469-474, 1989.

Stein, E.A. and G.J. Trachte. Thromboxane A2 augments adrenergic neurotransmission. Eicosanoids 3:205-211, 1990.

Trachte, G.J., K. Meixner, C.M. Ferrario and M.C. Khosla: Prostaglandin production in response to angiotensin-(1-7) in rabbit isolated vas deferens. Prostaglandins 39:385-394, 1990.

Trachte, G.J. and L.J. Heller: Adenosine receptor antagonism attenuates angiotensin II effects on adrenergic neurotransmission in the rabbit isolated vas deferens. J. Pharmacol. Exp. Ther. 253:490-496, 1990.

Trachte, G.J.: Pharmacological differentiation of angiotensin effects in the rabbit isolated vas deferens with dithiothreitol and pertussis toxin. J. Pharmacol. Exp. Ther. 253:80-84, 1990.

Drewett, J.G., R.J. Ziegler and G.J. Trachte. Neuromodulatory effects of ANF are independent of guanylate cyclase in adrenergic, neuronal pheochromocytoma cells. J. Pharmacol. Exp. Ther. 255:497-503, 1990.

Trachte, G.J., C.M. Ferrario and M.C. Khosla: Selective blockade of angiotensin responses in the rabbit isolated vas deferens by angiotensin receptor antagonists. J. Pharmacol. Exp. Ther. 255:929-934, 1990.

Odean, M.J., G.J. Trachte and A.G. Johnson. Characterization of immune suppression induced by polyribonucleotides. Int. J. Immunopharmacology 13:339-348, 1991.

Fitzgerald, T.J., M.A. Tomai, G.J. Trachte and T. Rice: Prostaglandins in experimental syphilis: treponemes stimulate adherent spleen cells to secrete prostaglandin E2, and indomethacin upregulates immune functions.Infection and Immunity 59:143-149, 1991.

Waters, D.J., D.D. Caywood, G.J. Trachte, R.T. Turner and S.F. Hodgson. The effect of aspirin on bone mass and bone prostaglandin E in canine immobilization (disuse) osteoporosis. Acta Orthopaedica Scandinavica62:238-243, 1991.

Johnson, B.G., G.J. Trachte and J.G. Drewett: Neuromodulatory effect of the atrial natriuretic factor clearance receptor binding peptide, C-ANF(4-23)-NH2 in rabbit isolated vasa deferentia. J. Pharmacol. Exp. Ther.257:720-726, 1991.

Drewett, J.G., R.J. Ziegler and G.J. Trachte: Neuromodulatory effects of atrial natriuretic peptides correlate with an inhibition of adenylate cyclase but not an activation of guanylate cyclase. J. Pharmacol. Exp. Ther.260: 689-696, 1992.

Trachte, G.J.: Atrial natriuretic factor (ANF) alters neurotransmission independently of Guanylate cyclase-coupled receptors in the rabbit vas deferens. J. Pharmacol. Exp. Ther. 264: 1227-1233, 1993.

Kanwal, S. and G.J. Trachte: Potassium channel inhibitors attenuate neuromodulatory effects of atrial natriuretic factor in the rabbit isolated vas deferens. J. Pharmacol. Exp. Ther. 268: 117-123, 1994.

Trachte, G.J. and J.G. Drewett: C-type natriuretic peptide neuromodulates independently of guanylyl cyclase activation. Hypertension 23: 38-43, 1994.

Trachte, G.J., S. Kanwal, B.J. Elmquist and R.J. Ziegler: C-type natriuretic peptide neuromodulates via "clearance" receptors. Amer. J. Physiol., 268: C978-C984, 1995.

Kanwal, S., B.J. Elmquist and G.J. Trachte: Atrial natriuretic peptide inhibits evoked catecholamine release by altering sensitivity to calcium. J. Pharmacol. Exp. Ther. 283: 426-433, 1997.

Takida, S., B.J. Elmquist and G.J. Trachte: C-type natriruetic peptide attenuates evoked dopamine efflux by influencing Go? Hypertension 33: 124-129, 1999

Kanwal, S., D.G. Lowe and G.J. Trachte: Intracellular fragments of the natriuretic peptide receptor-C (NPR-C) attenuate dopamine efflux. Endocrinology 140: 1118-1124, 1999.

Trachte, G.J.: Depletion of natriuretic peptide C receptors eliminates inhibitory effects of C-type natriuretic peptide on evoked neurotransmitter efflux. J. Pharmacol. Exp. Ther. 294: 210-215, 2000

Trachte, G.J.: Urodilatin attenuates sympathetic neurotransmission in the rabbit isolated vas deferens without activating guanylyl cyclase. Life Sciences 69: 2833-2844, 2001.

Trachte, G.J.: Natriuretic peptidessuppress protein kinase C activity to reduce evoked dopamine efflux from Pheochromocytoma (PC12) cells. Endocrinology 144: 94-100, 2003.

Trachte, G.J. and Fitzakerley, J.L.: Reduced cochlear cyclic guanosine monophosphate concentrations parallel hearing loss in aging mice. Submitted for publication in Hearing Research (5/9/06)

Trachte G.J., Uncini T., and Hinz M.: Both stimulatory and inhibitory effects of dietary 5-hydroxytryptophan and tyrosine are found on urinary excretion of serotonin and dopamine in a large human population.Neuropsychiatr Dis Treat 5:227-35 (Epub 2009 May 20)

Teaching

Teaching Areas

    • Course Director for Respiratory Medicine 
    • Teach Autonomic Pharmacology in the following Medicine Blocks: 
    • Neuroscience
    • Musculoskeletal system
    • Respiratory
    • Cardiovascular
    • and Renal. 
    • Present lectures on megaloblastic anemia
    • congestive heart failure
    • and uterine motility. 
    • Participate in Problem Based Learning cases in Respiratory Medicine, Renal and Electrolytes, Musculoskeletal/Dermatology System and Medicine. 
    • Course Director for the undergraduate/graduate course Pharmacology 4001 (Drugs and Health)- deliver six lectures on autonomic pharmacology in hypertension, heart failure and myocardial infarction/angina. 
    • Course Director for the graduate Comparative Physiology course, Integrated Biosciences 8103